5/1/2023 0 Comments Sds drop analog rytm mkii![]() Liraglutide significantly down-regulated the expression of Bcl-2 and up-regulated that of Bax in the ipsilateral thalamus compared with the vehicle group. Liraglutide treatment decreased the neuronal loss, astroglial and microglial activation, and apoptosis compared with the vehicle treatment. Liraglutide treatment significantly reduced Aβ deposition compared with the vehicle treatment. The results showed that liraglutide improved sensory deficit compared to the controls. Terminal deoxynucleotidyl transferase 2’-deoxyuridine 5’-triphosphate nick end labeling and Western blot were used to detect neuronal apoptosis. Sensory function and secondary thalamic damage were assessed using adhesive-removal test and Nissl staining and immunostaining, respectively, at 7 days after MCAO. At 1 h after MCAO, rats in the liraglutide and vehicle groups were subcutaneously injected with liraglutide (100 μg/kg/d) and isopyknic vehicle, respectively, once a day for 7 days. Forty-two male Sprague–Dawley rats were subjected to distal middle cerebral artery occlusion (MCAO) and then randomly divided into liraglutide and vehicle groups, and 14 sham-operated rats as control. In addition, this study was conducted to investigate whether liraglutide could improve sensory function after focal cerebral infarction. ![]() ![]() The present study aimed to investigate the protective effects of liraglutide, a long-acting glucagon-like peptide-1 (GLP)-1 receptor agonist, on Aβ deposits and secondary damage in the ipsilateral thalamus after focal cerebral infarction. Thalamus is the subcortical center of sensory, the damage of thalamus could cause sensory deficits. 3Department of Neurology, Stroke Center, Zhuhai Hospital Affiliated with Jinan University, Zhuhai, Chinaįocal cerebral infarction causes β-amyloid (Aβ) deposition and secondary neuronal degeneration in the ipsilateral thalamus.2Clinical Neuroscience Institute, Jinan University, Guangzhou, China.1Department of Neurology and Stroke Center, The First Affiliated Hospital, Jinan University, Guangzhou, China.Hui-Li Zhu 1,2†, Zhang-Pei Liu 2,3†, Wan-Yong Yang 1,2, Da-Wei Dong 1,2, Ying Zhao 1,2, Bing Yang 1,2, Li-An Huang 1,2, Yu-Sheng Zhang 1,2*† and An-Ding Xu 1,2*†
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